18.07.2023Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress

Sirtuin (SIRT)1 activity exerts beneficial cardiovascular effects. In diabetes, plasma SIRT1 levels are decreased. In this translational study, Dr. Kangmin Yang and colleagues aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice.

Yang et al. found that chronic rmSIRT1 supplementation improves endothelial function and vascular compliance by enhancing eNOS activity and suppressing NOX-related oxidative stress. These findings suggest that SIRT1 supplementation may represent a novel therapeutic strategy to prevent diabetic vascular disease.

Florian Wenzl