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Progeria is an extremely rare genetic disease caused by mutation in LMNA gene, which results in progressive premature aging and shortened lifespan. Arterial thrombosis-related events, such as ischemic stroke and myocardial infarction, are two main causes of death in children suffering from this genetic disease. A recent study by Dr. Puspitasari and colleagues reports enhanced arterial thrombus formation in animals bearing the LMNA mutation, in which platelets were one of the determinants of this phenomenon.
