14.07.2020Anti-inflammatory treatment after ischemic stroke as a novel therapeutic approach?

In this report, Liberale and associates demonstrate that IL-1α plays an important role in the aggravation of stroke and that neutralizing IL-α exerts beneficial effects on outcome in mice upon ischemic stroke. The availability of an antihuman IL-1α antibody already in clinical use offers translational potential to these observations. Randomized clinical trials should assess the potential of anti–IL-1α therapy as an adjuvant to interventional or thrombolytic treatment of acute ischemic strokes.